Excessive accumulation of candidate gene polymorphisms in young hypertensive patients as a factor of increasing incidence of arterial hypertension at a young age

Abstract The concept of accumulation candidate genes (CG) polymorphisms in the realization hypertensive phenotype is perspective both understanding about arterial hypertension (AH) formation as a disease with constant increasing incidence, and prognosis early prevention. purpose research was to check hypothesis excessive genetic young patients compared older non-hypertensive factor morbidity AH at age modern population. prevalence AH-associated these groups studied calculation gene modification index (GMI). Methods 204 (mean 42,4 [18–75], m/f 108/96), (ESC/ISH 2018) 102 without 40,1 [18–69], 55/47) were examined. Hypertensive (HP) divided into 2 depending on (WHO, 2016): group 1 – from 18 44 y.o. (n=98, 54/44); 45 more (n=106, 54/52); 3 (control) (non-HP). Patients analysed following CG by PCR: ADD1:1378, AGT:704, AGT:521, AGTR1:1166, AGTR2:1675, CYP11B2:-344, GNB3:825, NOS3:-786, NOS3:894. GMI represents percentage “pathological” genotypes. 0 20% considered low risk (GR), 21 40% moderate GR, 41 70% high 71 100% very GR. Results In HP average 60,2% [CI 95%, 24–79], while 7 (7.1%) had 22 (22,4%) GR 42 (42,9%), - 27 (27,6%) patients. 39,1% 18–70], (25,5%) 37 (34,9%) 25 (23,6%), 17 (16,0%) non-HP 20,1% 11–48], 84 (82,4%) patients, 13 (12,7%), 5 (4,9%), absent. Analyzing indicators between groups, natural significant difference levels revealed. So, (60,2% vs 20,1%, p=0,0002), (39,1% p=0,002). Also, revealed age. Thus, frequency (7,1% 25,5%, p=0,004), (42,9% 23,6%, p=0,009). Conclusions has significantly higher associated an which strong influencing incidence future can be used for progress Funding Acknowledgement Type funding sources: None.